Development Of Lipid-Based Micro Suspensions For Ophthalmic Delivery Of Gentaamicin – complete project material

[ad_1]

BSTRACT

The bioavailability of drugs from conventional eye drops is generally low. Many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. In this study, lipid-based microsuspensions of gentamicin were developed and investigated as alternative for ophthalmic delivery of gentamicin.
Lipid matrices used were prepared by fusion using 1:1, 1:2 and 2:1 mixtures of Phospholipon ? 90G and Softisan ? 154. Gentamicin (0.1, 0.3, 0.5 and 0.7 w/w %) was incorporated into the lipid matrices and microsuspensions were formulated by melt homogenization technique. The microsuspensions for topical ophthalmic delivery were characterized in terms of particle size and morphology, thermal analysis, osmolarity, entrapment efficiency and loading capacity. The in vitro release study of gentamicin in phosphate buffer (pH 7.4) was carried out using polycarbonate dialysis membrane (MWCO 6000-8000) while the ex vivo permeation studies were conducted using excised pig cornea. The permeability coefficient and flux of the formulation across the excised cornea were determined.
The particle size of the formulations ranged from 9.15 ? 1.04 to 12.91 ? 0.5 ?m. The microsuspensions had entrapment efficiency range of 25 -64%, which were dependent on the concentration of drug. The osmolarity of the formulation was within the range of 280.33 ? 3.05 -321.67 ? 2.08 mOsmol. The formulations were stable within the period of study. The lipid based formulations exhibited 49 -88% drug release in vitro at 12 h and the release was dependent on the ratio of the lipids used. There was sustained permeability of the formulations through the excised cornea when compared with commercial gentamicin eye drop. The lipid based microsuspensions could be used for ophthalmic.

GET THE COMPLETE PROJECT»

Do you need help? Talk to us right now: (+234) 8111770269, 08111770269 (Call/WhatsApp). Email: projects@blazingprojects.com. Disclaimer: This PDF Material Content is Developed by the copyright owner to Serve as a RESEARCH GUIDE for Students to Conduct Academic Research. You are allowed to use the original PDF Research Material Guide you will receive in the following ways: 1. As a source for additional understanding of the project topic. 2. As a source for ideas for you own academic research work (if properly referenced). 3. For PROPER paraphrasing ( see your school definition of plagiarism and acceptable paraphrase). 4. Direct citing ( if referenced properly). Thank you so much for your respect for the authors copyright.

[ad_2]


Purchase Detail

Hello, we’re glad you stopped by, you can download the complete project materials to this project with Abstract, Chapters 1 – 5, References and Appendix (Questionaire, Charts, etc) for N4000 ($15) only, To pay with Paypal, Bitcoin or Ethereum; please click here to chat us up via Whatsapp.
You can also call 08111770269 or +2348059541956 to place an order or use the whatsapp button below to chat us up.
Bank details are stated below.

Bank: UBA
Account No: 1021412898
Account Name: Starnet Innovations Limited

The Blazingprojects Mobile App



Download and install the Blazingprojects Mobile App from Google Play to enjoy over 50,000 project topics and materials from 73 departments, completely offline (no internet needed) with the project topics updated Monthly, click here to install.

0/5 (0 Reviews)
Read Previous

REPAIR AND RECOMMISSIONING OF PROCESS HEAT TRANSFER APPARATUS – Complete project material

Read Next

A Critical Evaluation Of David Hume’s Critique Of Natural Religion – complete project material

Need Help? Chat with us